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Clinical Trials in Diabetic Retinopathy

Drs. Harry W. Flynn, Jr. and Nidhi Relhan, Bascom Palmer Eye Institute, Miami, FL, shared their comprehensive document on Clinical Trials in Diabetic Retinopathy. This document is a compilation of the major clinical trials conducted over the past four decades for Diabetic Retinopathy.

The Clinical Trials in Diabetic Retinopathy document is organized into the following categories:

  1. Laser Trials – Highlights the recommendations and results of DRS, ETDRS, and various DRCR protocols (Protocol A, B, F, K and V)
  2. Pharmacotherapy Trials – Provides information on the role of intravitreal drugs used in the management of DME, outcomes and recommendations for diabetic retinopathy (DME and PDR).
  3. Vitreoretinal Surgery Trials – Vitreoretinal surgery in the management of diabetic retinopathy and its indications are explored.
  4. Medical Management Trials – Evidence based effect of control of systemic parameters and their effect on the overall management of diabetic retinopathy is reviewed in this section.
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Endophthalmitis Cookbook

This outline was created in the early 1980s as part of an Instructional Course at the annual meeting of the American Academy of Ophthalmology. The purpose of the course was to discuss basic treatment strategies for endophthalmitis including intravitreal and systemic antibiotics as well as to review various categories of endophthalmitis.

Over the years, the outline expanded to include incidence rates, specific treatments for each category and a section on prevention of endophthalmitis following ocular procedures.  The references have been expanded to include new and timely articles of interest to clinicians managing these patients.  

Because many of these patients present on weekends and after clinic hours, the outline became known as “the Cookbook” as it became a useful document for managing patients without the help of consultants during normal clinic hours.  The document is not intended to cover all published approaches but generally covers the mainstream of endophthalmitis treatment.